MIBiG Protein Description MIBiG Cluster MiBiG Product % ID % Coverage BLAST Score E-value
AAN79649.1 3-oxoacyl-[acyl-carrier_protein]_reductase BGC0000836 Other 58.0 100.4 265.0 6.2e-71
WP_045972731.1 3-oxoacyl-ACP_reductase_FabG BGC0002008 Other 57.0 100.4 261.0 1.5e-69
AAW85354.1 3-oxoacyl-(acyl-carrier-protein)_reductase,_putative BGC0000837 Other 52.0 100.0 247.0 3e-65
ABQ04140.1 short-chain_dehydrogenase/reductase_SDR BGC0000838 Polyketide 45.0 101.3 201.0 1.9e-51
ACU59350.1 short-chain_dehydrogenase/reductase_SDR BGC0000839 Other 41.0 100.8 187.0 2.8e-47
WP_018540601.1 SDR_family_oxidoreductase BGC0001332 NRP + Polyketide 42.0 99.6 174.0 1.9e-43
BAX64254.1 ketoreductase BGC0001623 NRP + Polyketide 42.0 99.2 171.0 2.1e-42
QBG38776.1 Atr15 BGC0001975 NRP 41.0 100.4 171.0 2.1e-42
BAO98807.1 putative_ketoreductase BGC0001002 NRP + Polyketide 40.0 105.9 169.0 7.9e-42
ALG65299.1 Cal37 BGC0001297 NRP 42.0 100.0 168.0 1.8e-41
QED88053.1 3-oxoacyl-ACP_reductase BGC0001967 NRP 41.0 99.6 165.0 8.7e-41
AEA30269.1 putative_3-oxoacyl-ACP_reductase BGC0000429 Polyketide + NRP:Cyclic depsipeptide 40.0 103.8 160.0 4.8e-39
AMK51286.1 Hex29 BGC0001376 Polyketide 40.0 102.5 159.0 8.1e-39
AFV52172.1 ketoreductase BGC0000081 Polyketide:Iterative type I + Polyketide:Enediyne type I 39.0 103.3 157.0 2.4e-38
AAQ08912.1 putative_3-ketoacyl-ACP_reductase BGC0000224 Polyketide:Type II 38.0 103.3 155.0 9e-38
AIL50168.1 putative_ketoreductase BGC0000213 Polyketide:Type II 39.0 102.1 154.0 2e-37
WP_054234634.1 SDR_family_oxidoreductase BGC0002014 NRP + Polyketide 37.0 100.4 154.0 2e-37
ADG86311.1 3-ketoacyl_ACP-reductase BGC0000190 Polyketide 38.0 103.8 151.0 1.3e-36
AET51861.1 3-ketoacyl_ACP_reductase BGC0001138 Other:Nucleoside 38.0 101.7 149.0 6.5e-36
ABC42552.1 putative_3-ketoacyl_ACP_reductase BGC0000698 Saccharide 36.0 101.3 147.0 3.2e-35
AAL15605.1 SimJ2 BGC0000270 Polyketide 38.0 101.3 144.0 2.7e-34
AAG34189.1 SimJ2 BGC0000835 Polyketide 38.0 101.3 144.0 2.7e-34
AAK06809.1 putative_3-keto-acyl-reductase_SimD4 BGC0001072 Saccharide + Polyketide:Modular type I + Polyketide:Type II + Other:Aminocoumarin 38.0 101.3 144.0 2.7e-34
QCT05738.1 Tri5 BGC0001983 Other 40.0 100.4 143.0 3.5e-34
AAM33668.1 putative_3-oxoacyl-ACP_reductase BGC0000230 Polyketide:Type II 36.0 102.9 143.0 6e-34
ABM21753.1 PdmG BGC0000256 Polyketide 36.0 100.8 142.0 7.9e-34
AAF23366.1 PhaB BGC0000866 Other 38.0 100.4 141.0 1.3e-33
OOH83075.1 3-oxoacyl-ACP_reductase BGC0001987 Polyketide 36.0 101.3 139.0 6.7e-33
AMK51276.1 Hex19 BGC0001376 Polyketide 38.0 100.8 138.0 1.5e-32
AAG03071.1 putative_reductase BGC0000266 Polyketide 33.0 102.5 136.0 5.7e-32
ANC94959.1 AlmK BGC0001396 Polyketide 36.0 102.1 136.0 5.7e-32
AAS79466.1 putative_post-PKS_ketoreductase BGC0000035 Polyketide 36.0 101.7 136.0 7.4e-32
ABB52548.1 3-oxoacyl-(acyl-carrier-protein)-reductase BGC0000047 Polyketide 35.0 102.1 135.0 1.3e-31
AIL50182.1 putative_ketoreductase BGC0000213 Polyketide:Type II 38.0 100.8 135.0 1.3e-31
AAO39097.1 AdmC BGC0000956 NRP:Beta-lactam + Polyketide:Type II 35.0 102.9 135.0 1.3e-31
BBC20651.1 enoyl-(acyl_carrier_protein)_reductase BGC0001917 Polyketide 35.0 101.7 134.0 2.1e-31
ADI58639.1 Ketoreductase BGC0000187 Polyketide:Type II 38.0 100.8 134.0 2.8e-31
BAJ52686.1 putative_3-oxoacyl-ACP_reductase BGC0000222 Polyketide 37.0 101.7 133.0 3.7e-31
CAM58804.1 C-19_ketoreductase BGC0000204 Polyketide:Type II 36.0 102.5 133.0 4.8e-31
CAD62198.1 Ata4_protein BGC0000873 Other 35.0 102.5 131.0 2.4e-30
AXM42926.1 ketoacyl_reductase BGC0001940 Polyketide 36.0 105.9 128.0 1.2e-29
ADG86325.1 ketoreductase BGC0000190 Polyketide 35.0 103.8 127.0 2.6e-29
BAJ52708.1 putative_3-ketoacyl-ACP_reductase BGC0000222 Polyketide 33.0 100.4 127.0 3.4e-29
WP_029025960.1 SDR_family_oxidoreductase BGC0000198 Polyketide:Type II + Saccharide:Hybrid/tailoring 37.0 102.5 125.0 1e-28
AHX24712.1 3-oxoacyl-ACP_reductase BGC0000200 Polyketide:Type II + Saccharide:Hybrid/tailoring 34.0 100.8 123.0 3.8e-28
AMX23331.1 putative_acyl_carrier_protein BGC0001500 Polyketide 32.0 100.8 123.0 6.5e-28
AAQ08926.1 putative_3-ketoacyl-ACP_reductase BGC0000224 Polyketide:Type II 33.0 101.3 121.0 1.9e-27
ABW11827.1 short-chain_dehydrogenase/reductase_SDR BGC0001197 Polyketide 33.0 100.8 121.0 1.9e-27
AHX24706.1 3-oxoacyl-ACP_reductase BGC0000200 Polyketide:Type II + Saccharide:Hybrid/tailoring 33.0 102.5 121.0 2.5e-27
CAC44199.1 ketoacyl_reductase BGC0000194 Polyketide:Type II 35.0 104.6 120.0 3.2e-27
AAM12916.1 MupD BGC0000182 Polyketide:Iterative type I + Polyketide:Trans-AT type I 34.0 100.8 120.0 4.2e-27
AAM33685.1 putative_bifunctional_cyclase/3-oxoacyl-ACP_reductase BGC0000230 Polyketide:Type II 33.0 102.1 120.0 4.2e-27
BAE71323.1 reductase/dehydrogenase BGC0000004 Polyketide 34.0 106.7 119.0 5.5e-27
AMK51287.1 Hex30 BGC0001376 Polyketide 34.0 101.3 119.0 9.3e-27
ARD70870.1 Polyketide_synthesis,_ketoreductase BGC0001693 Polyketide 33.0 106.3 118.0 1.2e-26
AAG03070.2 RubF BGC0000266 Polyketide 33.0 101.7 117.0 3.6e-26
ERG36779.1 3-oxoacyl-[acyl-carrier-protein]_reductase_FabG BGC0000299 NRP 34.0 103.8 116.0 4.6e-26
WP_010369414.1 SDR_family_oxidoreductase BGC0000314 Polyketide + NRP:Cyclic depsipeptide + Other:Aminocoumarin 34.0 103.8 116.0 4.6e-26
AWM72915.1 3-oxoacyl-ACP_reductase BGC0001719 Polyketide 36.0 102.1 116.0 4.6e-26
AHL46721.1 ketoreductase BGC0001179 Polyketide:Type II 37.0 102.1 116.0 7.9e-26
CAM34370.1 putative_3-oxoacyl-ACP_reductase BGC0000242 Polyketide 32.0 100.8 115.0 1e-25
AHL46681.1 ketoreductase BGC0001177 Polyketide:Type II 35.0 102.9 115.0 1e-25
ACH85584.1 putative_3-oxoacyl-ACP_reductase BGC0000283 Other:Cyclitol 31.0 101.3 115.0 1.3e-25
BAJ07854.1 putative_ketoreductase BGC0000232 Polyketide 33.0 107.9 114.0 1.8e-25
AHZ61856.1 short-chain_dehydrogenase/reductase BGC0000240 Polyketide:Type II + Saccharide:Hybrid/tailoring 33.0 107.5 114.0 1.8e-25
BBC20652.1 enoyl-(acyl_carrier_protein)_reductase BGC0001917 Polyketide 34.0 105.0 114.0 1.8e-25
ADB23387.1 dehydrogenase BGC0001062 Polyketide 32.0 100.8 114.0 2.3e-25
AQW35057.1 3-oxoacyl-ACP_reductase BGC0001675 Polyketide 34.0 102.5 114.0 2.3e-25
ADE22321.1 3-oxoacyl-ACP_reductase BGC0000279 Polyketide 32.0 100.8 114.0 3e-25
CAH10175.1 ChaZ_protein BGC0000207 Polyketide 33.0 105.4 112.0 8.7e-25
CAG23976.1 3-oxoacyl-(acyl_carrier_protein)_reductase BGC0000176 Polyketide + NRP 30.0 103.8 112.0 1.1e-24
CBH32818.1 putative_ketoreductase BGC0000263 Polyketide 32.0 105.9 112.0 1.1e-24
AFO85456.1 reductase/oxidase BGC0000391 NRP 32.0 99.6 109.0 5.7e-24
BAU79605.1 short-chain_dehydrogenase/reductase BGC0001810 Polyketide 32.0 102.1 109.0 7.4e-24
AAL15583.1 Sim5 BGC0000270 Polyketide 32.0 106.7 108.0 1.6e-23
AAK06787.1 putative_ketoreductase_SimA6 BGC0001072 Saccharide + Polyketide:Modular type I + Polyketide:Type II + Other:Aminocoumarin 32.0 106.7 108.0 1.6e-23
AAA65204.1 daunorubicin-doxorubicin_polyketide_synthase BGC0000218 Polyketide 32.0 104.6 108.0 2.2e-23
AEI98650.1 CtcG BGC0000209 Polyketide 34.0 104.6 106.0 4.8e-23
AFN69430.1 ElxO BGC0000509 RiPP:Lanthipeptide 29.0 102.5 106.0 4.8e-23
AGO50613.1 ketoreductase BGC0000229 Polyketide:Type II + Saccharide:Hybrid/tailoring 32.0 105.9 106.0 6.3e-23
AUI41032.1 3-oxoacyl-(acyl-carrier_protein)_reductase BGC0001512 Polyketide 30.0 102.9 105.0 1.4e-22
ADI71446.1 putative_ketoreductase BGC0000203 Polyketide 33.0 107.9 104.0 3.1e-22
ADE34491.1 ssfU BGC0000269 Polyketide:Type II + Saccharide:Hybrid/tailoring 32.0 104.6 103.0 4.1e-22
AJI44188.1 hypothetical_protein BGC0001193 NRP 31.0 101.7 103.0 4.1e-22
AAZ78333.1 OxyJ BGC0000254 Polyketide 31.0 106.3 103.0 5.3e-22
AFJ52673.1 C-9_ketoreductase BGC0001073 NRP + Polyketide 32.0 105.4 103.0 5.3e-22
AAD37452.1 putative_ketoacyl_reductase BGC0000252 Polyketide 35.0 101.7 102.0 6.9e-22
ABX71123.1 Lct40 BGC0000238 Polyketide 31.0 102.5 102.0 9.1e-22
AAT12286.1 LtxD BGC0000384 NRP 31.0 101.7 102.0 9.1e-22
ATZ52740.1 Bcaba4 BGC0001893 Other 33.0 105.4 102.0 9.1e-22
BAF85836.1 C5-ketoreductase BGC0000109 Polyketide 32.0 109.2 102.0 1.2e-21
AAA87616.1 polyketide_reductase BGC0000217 Polyketide 32.0 105.0 102.0 1.2e-21
AIE54248.1 PauY28 BGC0001732 Other 31.0 105.4 101.0 1.5e-21
AHZ20771.1 3-oxoacyl-acyl-carrier-protein_reductase BGC0000369 NRP + Saccharide:Hybrid/tailoring 32.0 105.0 100.0 3.4e-21
AIE54195.1 Pau28 BGC0001731 Other 31.0 105.4 100.0 4.5e-21
ACN38371.1 short-chain_dehydrogenase/reductase BGC0000714 Saccharide 32.0 102.1 99.0 5.9e-21
antaM 3-oxoacyl-ACP_reductase BGC0001455 NRP + Polyketide 31.0 107.5 99.0 5.9e-21
AEW19840.1 oxidoreductase,_short_chain_dehydrogenase/reductase_family_protein BGC0001651 Other 31.0 103.8 99.0 5.9e-21
CAB15190.2 2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase BGC0000309 NRP 30.0 106.7 99.0 7.7e-21
CAE53341.1 putative_short_chain_dehydrogenase BGC0000440 NRP:Glycopeptide 31.0 103.3 99.0 7.7e-21
CAG15000.1 short_chain_dehydrogenase BGC0000441 NRP 31.0 103.3 99.0 7.7e-21
AKA54637.1 3-oxoacyl-ACP_reductase BGC0001216 NRP + Polyketide 30.0 104.6 99.0 7.7e-21
AAF81727.1 putative_ketoreductase_EncD BGC0000220 Polyketide:Type II 32.0 107.5 98.0 1.7e-20
EHM27510.1 monooxygenase_FAD-binding BGC0000235 Polyketide 32.0 106.7 97.0 2.9e-20
WP_010639249.1 SDR_family_oxidoreductase BGC0000958 NRP:Cyclic depsipeptide + Polyketide:Modular type I 30.0 104.6 97.0 2.9e-20
PPQ57494.1 monooxygenase BGC0002016 Polyketide 29.0 106.7 97.0 2.9e-20
CZT62787.1 3-oxoacyl-(Acyl-carrier-protein)_reductase,_involved_in_Hassallidin_biosynthesis BGC0001614 NRP 31.0 109.2 96.0 5e-20
AAG30255.1 NADPH-dependent_acetoacetyl_CoA_reductase BGC0000867 Other 35.0 77.0 95.0 1.1e-19
AEF33074.1 3-oxoacyl-[acyl-carrier_protein]_reductase BGC0001039 NRP + Polyketide 28.0 102.1 95.0 1.1e-19
WP_040253449.1 SDR_family_NAD(P)-dependent_oxidoreductase BGC0001596 Polyketide 31.0 104.6 95.0 1.1e-19
CAA74346.1 oxidoreductase BGC0000507 RiPP:Lanthipeptide 29.0 104.2 95.0 1.4e-19
AAM33669.1 putative_3-oxoacyl-ACP_reductase_GrhO2 BGC0000230 Polyketide:Type II 28.0 105.0 94.0 3.2e-19
BAJ07846.1 putative_oxygenase-reductase BGC0000232 Polyketide 33.0 107.5 94.0 3.2e-19
ACM68688.1 AerF BGC0000298 NRP 29.0 107.1 93.0 4.2e-19
XP_003044553.1 hypothetical_protein BGC0001768 NRP 33.0 108.4 93.0 5.5e-19
AHH25583.1 1-cyclohexenylcarbonyl_CoA_reductase BGC0000957 NRP + Polyketide 31.0 101.7 92.0 7.2e-19
CBZ42141.1 Acyl-Co_Adehydrogenase BGC0001117 NRP 29.0 111.3 92.0 7.2e-19
CAC37883.1 CpkI;_Nicotinamide-dependent_dehydrogenase BGC0000038 Polyketide:Modular type I 31.0 103.8 91.0 1.6e-18
ADB02849.1 AzicF BGC0000202 Polyketide 31.0 105.4 91.0 1.6e-18
CAE15172.1 BGC0001736 NRP 29.0 104.2 91.0 1.6e-18
NP_443952.1 short_chain_dehydrogenase/reductase BGC0001605 Terpene 31.0 105.0 91.0 2.1e-18
AAP11948.1 Short_chain_dehydrogenase BGC0000612 RiPP:Thiopeptide 30.0 103.3 91.0 2.7e-18
CAQ64702.1 probable_glucose_dehydrogenase BGC0000087 Polyketide 32.0 103.3 90.0 3.6e-18
CAA07756.1 ketoreductase BGC0000246 Polyketide 30.0 102.9 90.0 3.6e-18
CAK50776.1 ketoreductase BGC0000247 Polyketide:Type II + Saccharide:Oligosaccharide 30.0 102.9 90.0 3.6e-18
AAK57530.1 PgaM BGC0000262 Polyketide:Type II + Saccharide:Hybrid/tailoring 30.0 107.5 90.0 3.6e-18
AAX57196.2 auricin_polyketide_oxygenase-reductase BGC0000201 Polyketide:Type II + Saccharide:Hybrid/tailoring 30.0 105.9 90.0 4.6e-18
ADI71448.1 putative_oxygenase-reductase BGC0000203 Polyketide 29.0 106.3 90.0 4.6e-18
QDQ37901.1 NADP+-dependent_oxidoreductase BGC0001979 Polyketide 32.0 105.0 90.0 4.6e-18
QDG00821.1 oxygenase-reductase BGC0002028 Polyketide 33.0 107.9 90.0 4.6e-18
CAE45662.1 putative_ketoreductase BGC0000031 Polyketide:Modular type I 34.0 103.8 89.0 7.9e-18
ABD29269.1 3-ketoacyl-acyl_carrier_protein_reductase,_putative BGC0000943 Other 26.0 107.1 89.0 1e-17
ALV82326.1 putative_reductase BGC0001533 Polyketide 32.0 104.6 89.0 1e-17
AAP13848.2 C5-ketoreductase BGC0000093 Polyketide 30.0 109.6 88.0 1.8e-17
AEH42481.1 2,3-dihydroxybenzoate-2,3-dehydrogenase BGC0000032 Polyketide 29.0 107.9 87.0 2.3e-17
BAV17004.1 putative_oxygenase-reductase BGC0001384 Polyketide 31.0 104.6 87.0 2.3e-17
AGH68923.1 oxidoreductase BGC0001083 Terpene + Polyketide:Type III 29.0 105.0 87.0 3e-17
AAQ84160.1 ChcA BGC0000123 Polyketide 32.0 101.7 87.0 3.9e-17
AHG26146.1 quinone_reductase BGC0000812 Alkaloid 36.0 67.8 87.0 3.9e-17
ADI58630.1 1-Cyclohexenylcarbonyl_CoA_reductase BGC0000187 Polyketide:Type II 30.0 102.1 86.0 5.1e-17
AIE54187.1 Pau20 BGC0001731 Other 28.0 107.9 86.0 6.7e-17
AIE54240.1 PauY20 BGC0001732 Other 28.0 107.9 86.0 6.7e-17
CAH10112.1 putative_oxidase-reducatse BGC0000268 Polyketide 27.0 105.9 85.0 1.1e-16
CAE45661.1 putative_ketoreductase BGC0000031 Polyketide:Modular type I 35.0 60.3 85.0 1.5e-16
ALV82322.1 ketoreductase BGC0001533 Polyketide 35.0 60.3 85.0 1.5e-16
ARO44645.1 monooxygenase BGC0001769 Polyketide 29.0 104.2 85.0 1.5e-16
CAM34373.1 putative_reductase BGC0000242 Polyketide 27.0 105.0 84.0 2.6e-16
ACY06294.1 short-chain_dehydrogenase/reductase BGC0001042 NRP + Polyketide 27.0 101.7 84.0 2.6e-16
AWM95785.1 short_chain_dehydrogenase BGC0001827 Polyketide 29.0 101.7 83.0 5.7e-16
AGO50615.1 oxygenase-reductase BGC0000229 Polyketide:Type II + Saccharide:Hybrid/tailoring 27.0 104.2 82.0 1.3e-15
ACP19359.1 SaqN BGC0000267 Polyketide:Type II + Saccharide:Oligosaccharide 31.0 104.2 81.0 1.7e-15
EWM63056.1 2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase BGC0000679 Terpene 27.0 106.7 81.0 2.8e-15
CAA09651.1 BGC0000227 Polyketide:Type II 28.0 105.4 80.0 3.7e-15
CAA34367.1 BGC0000228 Polyketide 28.0 105.4 80.0 3.7e-15
BAL90266.1 putative_short-chain_dehydrogenase BGC0002021 Polyketide 29.0 105.4 80.0 3.7e-15
CCM44333.1 3-oxoacyl-ACP_reductase BGC0001056 NRP + Polyketide:Modular type I + Polyketide:PUFA synthase or related 30.0 104.6 80.0 4.8e-15
AXO35180.1 2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase BGC0001848 Other 28.0 106.7 80.0 4.8e-15
ANY57882.1 PenD BGC0001372 Terpene 31.0 107.9 79.0 1.1e-14
ACN64844.1 PokT1 BGC0001061 Polyketide:Iterative type I + Polyketide:Type II + Saccharide:Hybrid/tailoring 28.0 103.8 78.0 1.4e-14
AAK06790.1 putative_reductase_SimA9 BGC0001072 Saccharide + Polyketide:Modular type I + Polyketide:Type II + Other:Aminocoumarin 27.0 105.9 78.0 1.4e-14
AAD13552.1 bifunctional_reductase_+_aromatase BGC0000239 Polyketide:Type II + Saccharide:Hybrid/tailoring 32.0 106.3 78.0 1.8e-14
AAL15586.1 Sim8 BGC0000270 Polyketide 27.0 105.9 77.0 2.4e-14
AHL46696.1 ketoreductase BGC0001177 Polyketide:Type II 29.0 108.4 75.0 1.2e-13
BAW27709.1 dehydrogenase BGC0001764 NRP 27.0 101.3 75.0 1.2e-13
CAA60458.1 ketoreductase/dehydrogenase BGC0001040 NRP + Polyketide 30.0 104.6 74.0 3.4e-13
AKD43505.1 Ketoreductase BGC0001409 Polyketide 28.0 101.3 73.0 5.9e-13
ARF06204.1 short-chain_dehydrogenase/reductase_SDR BGC0001593 NRP 27.0 102.5 69.0 6.5e-12
BBG91916.1 type_I_PKS BGC0001927 Other 30.0 101.7 69.0 6.5e-12
AAA65202.1 daunorubicin-doxorubicin_polyketide_synthase BGC0000218 Polyketide 30.0 105.4 66.0 9.4e-11
AAF81238.1 putative_beta-ketoacyl_reductase BGC0000243 Polyketide 27.0 110.0 66.0 9.4e-11
ACA34721.1 CtnE BGC0000894 Other 27.0 101.3 64.0 2.1e-10
ALI92649.1 CitE_dehydrogenase BGC0001338 Polyketide:Iterative type I 27.0 101.3 64.0 2.7e-10
CAJ42322.1 ketoreductase BGC0000273 Polyketide:Type II + Saccharide:Hybrid/tailoring 36.0 51.0 64.0 3.6e-10
BAJ07858.1 putative_ketoacyl_reductase BGC0000232 Polyketide 27.0 84.5 59.0 6.7e-09
AIG62141.1 isoepoxydon_dehydrogenase BGC0000120 Polyketide:Iterative type I 26.0 104.2 58.0 2e-08
AEE65483.1 short-chain_dehydrogenase/reductase_SDR BGC0000223 Polyketide:Type II 28.0 82.8 58.0 2e-08
AAN65227.1 b-ketotyrosyl-reductase BGC0000832 Saccharide:Hybrid/tailoring + Other:Aminocoumarin 29.0 98.3 57.0 2.6e-08
WP_099111428.1 SDR_family_oxidoreductase BGC0001826 NRP 25.0 104.6 57.0 4.4e-08
WP_003598534.1 SDR_family_oxidoreductase BGC0001991 Polyketide 29.0 79.1 51.0 2.4e-06
AAF67504.1 b-ketotyrosyl-reductase BGC0000834 Saccharide:Hybrid/tailoring + Other:Aminocoumarin 26.0 98.3 49.0 9.1e-06